{"id":17468,"date":"2024-01-18T15:17:18","date_gmt":"2024-01-18T14:17:18","guid":{"rendered":"https:\/\/provisorio1000.com.br\/novos-biomarcadores-de-exposicao-a-fumonisina-em-galinhas\/"},"modified":"2026-05-10T03:49:52","modified_gmt":"2026-05-10T01:49:52","slug":"novos-biomarcadores-de-exposicao-a-fumonisina-em-galinhas","status":"publish","type":"post","link":"https:\/\/provisorio1000.com.br\/pt-br\/novos-biomarcadores-de-exposicao-a-fumonisina-em-galinhas\/","title":{"rendered":"Novos biomarcadores de exposi\u00e7\u00e3o \u00e0 fumonisina em galinhas?"},"content":{"rendered":"[vc_row type=”in_container” full_screen_row_position=”middle” column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” scene_position=”center” constrain_group_4=”yes” text_color=”dark” text_align=”left” row_border_radius=”none” row_border_radius_applies=”bg” row_position_desktop=”default” row_position_tablet=”inherit” row_position_phone=”inherit” overflow=”visible” overlay_strength=”0.3″ gradient_direction=”left_to_right” shape_divider_position=”bottom” bg_image_animation=”none” gradient_type=”default” shape_type=””][vc_column column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” flex_gap_desktop=”10px” column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” column_position=”default” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid” column_padding_type=”default” gradient_type=”default”][vc_row_inner column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” top_padding=”2%” constrain_group_1=”yes” bottom_padding=”2%” text_align=”left” row_position=”default” row_position_tablet=”inherit” row_position_phone=”inherit” overflow=”visible” pointer_events=”all”][vc_column_inner column_padding=”padding-2-percent” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”left” left_margin=”7px” flex_gap_desktop=”10px” column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” overflow=”visible” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”advanced” border_left_desktop=”1″ column_border_color=”#269756″ column_border_style=”solid” column_padding_type=”default” gradient_type=”default”][vc_column_text el_class=”med”]A toxicidade das fumonisinas (FUM) est\u00e1 associada ao bloqueio das ceramida sintases (CerS), o que afeta o equil\u00edbrio de esfingolip\u00eddios como a esfinganina (Sa) e a esfingosina (So) nas c\u00e9lulas.<\/b>[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_row_inner column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” top_padding=”2%” constrain_group_1=”yes” bottom_padding=”2%” text_align=”left” row_position=”default” row_position_tablet=”inherit” row_position_phone=”inherit” overflow=”visible” pointer_events=”all”][vc_column_inner column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” flex_gap_desktop=”10px” column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” overflow=”visible” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid”][vc_column_text]Enquanto o \u00e1cido salic\u00edlico (Sa) se acumula nas c\u00e9lulas, o n\u00edvel de \u00e1cido som\u00e1tico (So) \u00e9 compensado, afetando assim a raz\u00e3o Sa:So, que \u00e9 usada como biomarcador de exposi\u00e7\u00e3o \u00e0 fumonisina em muitas esp\u00e9cies. No entanto, mecanismos compensat\u00f3rios para manter os n\u00edveis de ceramida nas c\u00e9lulas tornam o uso desse biomarcador irrelevante em alguns estudos (dependendo do n\u00edvel e da dura\u00e7\u00e3o da exposi\u00e7\u00e3o). De fato, neste estudo, a raz\u00e3o Sa:So n\u00e3o foi significativamente afetada no plasma de galinhas expostas a fumonisinas. Contudo, uma an\u00e1lise abrangente das diferentes classes de esfingolip\u00eddios revelou que a raz\u00e3o entre as formas fosfatadas de Sa e So (Sa1P:So1P) aumentou significativamente com a administra\u00e7\u00e3o de fumonisinas.<\/p>\n

Este resultado est\u00e1 de acordo com achados anteriores que sugerem que a raz\u00e3o Sa1P:So1P \u00e9 um biomarcador melhor da exposi\u00e7\u00e3o \u00e0 fumonisina no plasma do que a raz\u00e3o Sa:So. Efeitos semelhantes das fumonisinas foram observados dependendo do tamanho da cadeia carb\u00f4nica das ceramidas. <\/span><\/p>\n

Observou-se um aumento significativo na raz\u00e3o C22-C24:C16 no plasma. Embora os mecanismos subjacentes a esses efeitos ainda n\u00e3o sejam totalmente compreendidos, esse resultado sugere que as raz\u00f5es de esfingolip\u00eddios C22-C24:C16, em conjunto com a raz\u00e3o Sa1P:So1P, podem ser boas candidatas para revelar a exposi\u00e7\u00e3o \u00e0 fumonisina no plasma de frangos, em doses que n\u00e3o afetaram a raz\u00e3o Sa:So.[\/vc_column_text][image_with_animation image_url=”6291″ image_size=”full” max_width=”100%” max_width_mobile=”default” animation_type=”entrance” animation=”None” animation_movement_type=”transform_y” hover_animation=”none” alignment=”” border_radius=”none” box_shadow=”none” image_loading=”default”][vc_column_text]Figura: An\u00e1lises discriminantes (PLS-DA) de esfingolip\u00eddios no plasma de frangos alimentados com uma dieta controle livre de micotoxinas ou contendo aproximadamente 15 mg de FUM\/kg por 14 ou 21 dias.<\/span><\/em>[\/vc_column_text][vc_column_text]Refer\u00eancia: Lassallette E., Nyvall-Collen P., Guerre P., A esfingolipid\u00f4mica direcionada indica aumento nas propor\u00e7\u00f5es C22-C24:16 de praticamente todas as classes analisadas no f\u00edgado, rim e plasma de galinhas alimentadas com fumonisina. Ecotoxicology and Environmental Safety 268 (2023) 115697.<\/i>
\nhttps:\/\/doi.org\/10.1016\/j.ecoenv.2023.115697<\/a> <\/i>[\/vc_column_text][divider line_type=”Full Width Line” line_thickness=”1″ divider_color=”accent-color” custom_height=”20″][vc_column_text]Vous \u00eates int\u00e9ress\u00e9 par les travaux de cette \u00e9quipe de recherche sur les effets des fumonisines chez le poulet ?<\/b> Jetez un coup d’\u0153il \u00e0 leur \u00e9tude pr\u00e9c\u00e9dente sur l’accumulation de FUM dans le foie et les muscles du poulet<\/a><\/strong><\/span>, et sur la fa\u00e7on dont la technologie Algoclay d\u2019Olmix peut la r\u00e9duire<\/b>.<\/span>[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row]\n","protected":false},"excerpt":{"rendered":"

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